![]() ![]() ![]() (Another pathway requires B vitamins.) By lowering homocysteine levels, the risk of cardiovascular and cerebrovascular disease can be reduced.Īn early double-blind, cross-over study involving patients with elevated levels of homocystine (a metabolite of homocysteine) who received 3 grams oral betaine twice per day resulted in a significant decrease in average plasma homocysteine levels. Remethylation of homocysteine, a toxic amino acid formed from the essential amino acid methionine, can be accomplished via a pathway that involves TMG as a cofactor. Trimethylglycine is a methyl donor, which, by definition, donates methyl groups that consist of 1 carbon and 3 hydrogen atoms in a process known as methylation. Trimethylglycine is made in the bodies of most organisms from the nutrient choline.Ĭlinical Significance of Trimethylglycine It also occurs in such foods as quinoa, wheat bran and spinach. The compound was originally discovered in sugar beets. Trimethylglycine (TMG), also known as betaine or glycine betaine, is a derivative of the amino acid glycine. ![]()
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